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Linezolid (Linezolide) instructions for use.
The active substance (INN) Linezolid (Linezolide)
The use of Linezolid (Linezolide): Pneumonia (community-acquired and hospital), infections of skin and soft tissues, enterococcal infections, including caused by vancomycin-resistant strains of Enterococcus faecalis and Enterococcus faecium, and other infections caused by susceptible anaerobic and aerobic gram-positive bacteria, including infections accompanied by bacteremia.

Contra Linezolid (Linezolide): Hypersensitivity.

The use of Linezolid (Linezolide) during pregnancy and breastfeeding: Perhaps if the effect of therapy outweighs the potential risk to the fetus. Breast-feeding - with caution.

Side effects: Since the nervous system and sensory organs: more than 1% - a headache.
With the cardiovascular system and blood (hematopoiesis, hemostasis): more than 1% - deviation hematological parameters (reversible anemia, thrombocytopenia), increased blood pressure.
From the digestive tract: more than 1% - abdominal pain, cramps, bloating, diarrhea, nausea, deviation indicators of liver function (total bilirubin, ALT, AST, alkaline phosphatase), vomiting, dysgeusia, pseudomembranous colitis.
Other: more than 1% - candidiasis.

Interaction: Pharmacodynamic: enhances pressor effect of pseudoephedrine hydrochloride and phenylpropanolamine hydrochloride. Should not be mixed with sympathy and dofaminomimetikami, vasopressors.
Pharmacokinetic: The simultaneous use of Aztreonam and gentamicin (pharmacokinetics unchanged).

Overdose: Treatment: symptomatic therapy; activities aimed at maintaining the glomerular filtration, hemodialysis.

Dosing and Administration: inside, regardless of the meal, 2 times per day. Community-acquired and hospital pneumonia - 600 mg for 10-14 days of infection of skin and soft tissue - at 400-600 mg orally, depending on the severity of the disease, the treatment course of 10-14 days; enterococcal infections - 600 mg for 14 -28 days. Children from 5 years of the recommended dose is 10 mg / kg 2 times per day. The maximum daily dose for children and adults - 600 mg 2 times a day.

Precautions: Patients in hemodialysis, linezolid is administered after dialysis. One should bear in mind the possibility of pseudomembranous colitis, reversible anemia and thrombocytopenia (platelet counts should be monitored and hemoglobin levels in patients at risk of bleeding, anemia or thrombocytopenia in history, as well as simultaneously receiving drugs that reduce the level of hemoglobin or the number or functional properties of platelets, or receiving linezolid for more than 2 weeks).
Not recommended for patients with pheochromocytoma, carcinoid, thyrotoxicosis. If necessary, a joint appointment should adjust the dose of adrenergic drugs. During treatment, the need to avoid foods containing tyramine (including varietal beer, smoked ham).

Other drugs with working substance Linezolid (Linezolide)


Linezolid (Linezolide)

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